Edit Genome Manusia, Shortly Available !

” CRISPR/Cas9 and Targeted Genome Editing: A New Era in Molecular Biology

The development of efficient and reliable ways to make precise, targeted changes to the genome of living cells is a long-standing goal for biomedical researchers. Recently, a new tool based on a bacterial CRISPR-associated protein-9 nuclease (Cas9) from Streptococcus pyogenes has generated considerable excitement. This follows several attempts over the years to manipulate gene function, including homologous recombination and RNA interference (RNAi). RNAi, in particular, became a laboratory staple enabling inexpensive and high-throughput interrogation of gene function, but it is hampered by providing only temporary inhibition of gene function and unpredictable off-target effects. Other recent approaches to targeted genome modification – zinc-finger nucleases [ZFNs] and transcription-activator like effector nucleases [TALENs]– enable researchers to generate permanent mutations by introducing doublestranded breaks to activate repair pathways. These approaches are costly and time-consuming to engineer, limiting their widespread use, particularly for large scale, high-throughput studies.”

Pernahkah anda mendengar istilah gen terapi ? Sebelum ditemukan teknologi ini, gen terapi masih mengandalkan virus sebagai vektor pembawa. Penemuan terakhir menunjukkan bahwa teknologi genome editing dapat menjadi terobosan maju dalam menangani berbagai macam penyakit manusia- utamanya adalah penyakit genetik – ataupun kebutuhan akan energi terbarukan. Teknologi CRISPR/CAS9 telah membawa harapan gen terapi pada level aplikasi.

CRISPR/Cas9 System Applications


Teknologi genome editing dengan menggunakan CRISPR/Cas9 sebagai model baru gene editing dapat anda baca pada artikel asal berikut INI.

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